ap39 (Cayman Chemical)
90
Structured Review
Cayman Chemical
ap39
Ap39, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ap39/product/Cayman Chemical
Average 90 stars, based on 1 article reviews
Ap39, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ap39/product/Cayman Chemical
Average 90 stars, based on 1 article reviews
ap39 - by Bioz Stars,
2026-03
90/100 stars
Images
1) Product Images from "Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells"
Article Title: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells
Journal: Drug Design, Development and Therapy
doi: 10.2147/DDDT.S507697
Figure Legend Snippet: Physicochemical Properties of AP39. Results are Presented as the Mean ± Standard Deviation. n=4 Independent Batches
Techniques Used: Standard Deviation, Solubility
Figure Legend Snippet: Liposome Characteristics Showcasing Size, Polydispersity, Zeta Potential, and Entrapment Efficiency. Data Represents Mean ± SD. n=6 Independent Batches
Techniques Used: Zeta Potential Analyzer, Liposomes
Figure Legend Snippet: Cell viability evaluated on ( A ) HUVEC and ( B ) SHSY5Y cells following the application of AP39 in solution (non-formulated) and formulated AP39 into liposomes, assessed by LDH release. The percentage release of LDH (cytotoxicity) of each sample was subtracted from 100% viability of control (after 4 h of exposure). Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches.
Techniques Used: Liposomes, Control
Figure Legend Snippet: Liposomal AP39 provided a slow and sustained ( A ) cellular uptake of AP39 and ( B ) release of H 2 S from formulated AP39 compared to non-formulated AP39 on SHSY5Y cells. Hourly H 2 S release values are plotted with curve-fitting results to highlight the donor compound decomposition. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches. ***p ≤ 0.001.
Techniques Used:
Figure Legend Snippet: Liposomal AP39 formulation enhances the directional permeability of AP39. ( A ) AP39 permeation across a microvascular endothelial barrier model mimicking the Blood-Brain Barrier ( B ) TEER values measured following growth of HUVEC on permeable cell culture inserts (24-well, 0.33 cm2) under static conditions, before and after tight junction inducers. ( C ) AP39 apical to basolateral transport. ( D ) basolateral to apical transport. ( E ) Associated apparent membrane permeability (P app ) values in both directions. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 6. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001.
Techniques Used: Formulation, Permeability, Cell Culture, Membrane
Figure Legend Snippet: Mitochondrial oxygen consumption rates determined in SHSY5Y exposed to AP39 (in formulation or not) and in combination with H 2 O 2 (300 µM) for 1h. ( A ) Sequential injections of Oligomycin, FCCP and mixture of Rotenone and Antimycin A allowed to calculate the parameters of mitochondrial function, ( B ) basal respiration and maximal respiration. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001.
Techniques Used: Formulation